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Test Code ACHE_ Acetylcholinesterase, Amniotic Fluid (AChE-AF), Amniotic Fluid

Reporting Name

Acetylcholinesterase, AF

Useful For

Diagnosing open neural tube defects, and to a lesser degree, ventral wall defects

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Amniotic Fld

Specimen Required

Container/Tube: Amniotic fluid container

Specimen Volume: 1 mL

Collection Instructions: A specimen from the 14 to 18 week gestational period of pregnancy is preferred. Amniotic fluid from the 14 to 21 week gestational period is acceptable.

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Amniotic Fld Refrigerated (preferred) 365 days
  Frozen  365 days
  Ambient  14 days

Reference Values

Negative (reported as negative [normal] or positive [abnormal] for inhibitable acetylcholinesterase)

 

Reference values were established in conjunction with alpha-fetoprotein testing and include only amniotic fluids from pregnancies between 14 and 21 weeks gestation.

Day(s) and Time(s) Performed

Tuesday, Thursday; 8 a.m. (not reported on Saturday and Sunday)

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

82013

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ACHE_ Acetylcholinesterase, AF 30106-9

 

Result ID Test Result Name Result LOINC Value
9287 Acetylcholinesterase, AF 30106-9
GACHE Gestational Age (ACHE) 18185-9

Method Name

Polyacrylamide Electrophoresis

Forms

1. Second Trimester Maternal Screening Alpha-Fetoprotein (AFP)/QUAD Screen Patient Information (T595) is required; see Special Instructions.

2. New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing (T576) is available in Special Instructions.

Necessary Information

Gestational age at amniocentesis is required.

Additional Testing Requirements

If chromosome studies are also requested, see AF / Chromosome Analysis, Amniotic Fluid. The specimen for acetylcholinesterase testing, when requested with chromosome analysis, cannot be frozen.