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Test Code APCRR Activated Protein C Resistance V (APCRV), with Reflex to Factor V Leiden, Plasma

Useful For

Evaluation of patients with incident or recurrent venous thromboembolism (VTE)

 

Evaluation of individuals with a family history of VTE

Profile Information

Test ID Reporting Name Available Separately Always Performed
APCRV Activated Protein Resistance V, P Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
F5DNA Factor V Leiden (R506Q) Mutation, B Yes No
F5DNI APCRV/F5DNA Summary Interpretation No No

Testing Algorithm

If the Activated Protein C Resistance V assay ratio is abnormal, then the F5DNA / Factor V Leiden (R506Q) Mutation, Blood assay will be performed at an additional charge. An F5DNI / APCRV/F5DNA Summary Interpretation will be provided when the Activated Protein C Resistance V assay is abnormal or indeterminate and the Factor V Leiden (R506Q) Mutation assay is reflexed.

Method Name

Clot-Based Assay

Reporting Name

APCRV, w/Reflex, P

Specimen Type

Plasma Na Cit
Whole blood

Specimen Required

See Coagulation Studies in Special Instructions.

 

Blood and plasma are required.

 

Specimen Type: Whole blood

Container/Tube:

Preferred: Yellow top (ACD)

Acceptable: EDTA or sodium citrate

Specimen Volume: Full tube

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

Additional Information: Each molecular coagulation test requested must have its own tube.

 

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Polypropylene vial

Specimen Volume: 1 mL

Collection Instructions:

1. Spin down, remove plasma

2. Spin plasma again; remove plasma aliquot without disturbing bottom 0.5 mL

3. Freeze specimen aliquots immediately at or below -40 degrees C if possible, but no longer than 4 hours after collection.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. If priority specimen, mark request form, give reason, and request a call-back.

3. Each coagulation assay requested should have its own vial.

Specimen Minimum Volume

Plasma: 0.5 mL, Whole Blood: 3 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Na Cit Frozen 14 days
Whole blood Ambient (preferred) 7 days
  Frozen  14 days
  Refrigerated  14 days

Reference Values

APCRV RATIO

≥2.3

Pediatric reference range has neither been established nor is available in scientific literature. The adult reference range likely would be applicable to children older than 6 months.

Day(s) and Time(s) Performed

Monday through Friday

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

85307

LOINC Code Information

Test ID Test Order Name Order LOINC Value
APCRR APCRV, w/Reflex, P 13590-5

 

Result ID Test Result Name Result LOINC Value
APCR APCRV Ratio 13590-5
INT55 Interpretation 48591-2

Forms

1. Coagulation Patient Information Sheet (T675) in Special Instructions

2. New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing (T576) is available in Special Instructions.

Test Classification

See Individual Test IDs