Sign in →

Test Code MZIKV Zika Virus IgM Antibody Capture MAC-ELISA, Serum

Useful For

Screening for the presence of IgM-class antibodies to Zika virus in symptomatic patients


Evaluation of symptomatic nonpregnant individuals with recent travel to or residence in a region with documented local transmission of Zika virus

Testing Algorithm

The following algorithms are available in Special Instructions:

-Assessment for Zika Virus Infection in Nonpregnant Individuals

-Assessment for Zika Virus Infection in Pregnant Individuals

Method Name

IgM Antibody Capture Enzyme-Linked Immunosorbent Assay (MAC-ELISA)

Reporting Name

Zika Virus MAC-ELISA, IgM, S

Specimen Type


Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 2.5 mL

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen 30 days

Reference Values


Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 9 a.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test received Emergency Use Authorization from the U.S. Food and Drug Administration on August 17, 2016. The approval letter can be accessed here: This test is used per manufacturer's instructions. Details regarding the performance characteristics for the InBios ZIKV Detect IgM Capture ELISA, can be viewed here: Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
MZIKV Zika Virus MAC-ELISA, IgM, S 80824-6


Result ID Test Result Name Result LOINC Value
SZIKV Zika Virus MAC-ELISA IgM, S 80824-6
PREGO Pregnant? 11449-6
TRVL Travel to/Resident of Zika Region? 8691-8
SYMPS Current or prior Zika symptoms? 75325-1

Necessary Information

There are 3 ask-at-order entry questions that are required. The only acceptable answers are Yes or No.

Additional Testing Requirements

Due to similar clinical presentation and cross reactivity, testing for IgM-class antibodies to dengue virus, concurrently with Zika virus IgM testing, is strongly recommended (DENVP / Dengue Virus Antibody/Antigen Panel, Serum).

Advisory Information

This test is not intended for medical-legal use.


This is a screening test for Zika virus. A presumptive positive result requires confirmatory testing available from the CDC.