Sign in →

Test Code NONTP Neuro-Oncology Panel, Tumor

Useful For

Identifying mutations that may support a diagnosis for patients with tumors of the central nervous system

 

Identifying mutations that may help determine prognosis for patients with tumors of the central nervous system

 

Identifying central nervous system tumors that may respond to targeted therapies by assessing multiple gene targets simultaneously

 

Identifying specific mutations within genes known to be associated with response or resistance to specific cancer therapies

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SLIRV Slide Review in MG No, (Bill Only) Yes

Testing Algorithm

When this test is ordered, slide review will always be performed at an additional charge.

Method Name

Polymerase Chain Reaction (PCR)-Based Next-Generation Sequencing

(PCR is utilized pursuant to a license agreement with Roche Molecular Systems, Inc.)

Reporting Name

Neuro-Oncology Panel, Tumor

Specimen Type

Varies

Specimen Required

Preferred:

Specimen Type: Tissue

Container/Tube: Tissue block

Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block.

 

Acceptable:

Specimen Type: Tissue

Slides: 1 Stained and 10 unstained

Collection Instructions: Submit 1 slide stained with hematoxylin and eosin and 10 unstained, nonbaked slides with 5 micron-thick sections of the tumor tissue.


Advisory Information:

At least 20% tumor is required for this assay. The amount of tissue needed is dependent on a variety of preanalytical factors (eg, cellularity, ischemic time, fixation). In general, the minimum specimen adequacy for this test is approximately a 1 cm(2) area of tissue (can be over multiple slides) or 5,000 total cells.


Specimen Minimum Volume

Tissue: Entire block. Slides: One or more stained and coverslipped cytology slides with at least 5,000 total nucleated cells and at least 20% tumor cells

Specimen Stability Information

Specimen Type Temperature Time
Varies Ambient (preferred)
  Frozen 
  Refrigerated 

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81445

Targeted genomic sequence analysis panel, solid organ neoplasm, DNA analysis, and RNA analysis when performed, 5-50 genes (eg, ALK, BRAF, CDKN2A, EGFR, ERBB2, KIT, KRAS, NRAS, MET, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET), interrogation for sequence variants and copy number variants or rearrangements, if performed

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NONTP Neuro-Oncology Panel, Tumor 38179-8

 

Result ID Test Result Name Result LOINC Value
43685 Result Summary 50397-9
43686 Result 38179-8
43687 Interpretation 69047-9
43688 Additional Information 48767-8
43689 Specimen 31208-2
43690 Source 31208-2
43691 Tissue ID 81178-6
43692 Released By No LOINC Needed

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request Form (T729) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/oncology-request-form.pdf)