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Test Code PNEFC Neuroimmunology Antibody Follow-up, Spinal Fluid

Reporting Name

Neuroimmunology Ab Follow-up, CSF

Useful For

Monitoring patients who have previously tested positive for 1 or more antibodies within the past 5 years in a Mayo Clinic Neuroimmunology Laboratory evaluation

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

CSF


Advisory Information


This test is only appropriate for follow-up in patients who have previously tested positive in a spinal fluid test. If patients have not previously been positive in a spinal fluid test, order 1 of the following:

-PAC1 / Paraneoplastic, Autoantibody Evaluation, Spinal Fluid

-DMC1 / Dementia, Autoimmune Evaluation, Spinal Fluid

-ENC1 / Encephalopathy, Autoimmune Evaluation, Spinal Fluid

-EPC1 / Epilepsy, Autoimmune Evaluation, Spinal Fluid



Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 4 mL


Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

NEURONAL NUCLEAR ANTIBODIES

Antineuronal Nuclear Antibody-Type 1 (ANNA-1)

<1:2

Antineuronal Nuclear Antibody-Type 2 (ANNA-2)

<1:2

Antineuronal Nuclear Antibody-Type 3 (ANNA-3)

<1:2

Anti-Glial/Neuronal Nuclear Antibody-Type 1 (AGNA-1)

<1:2

 

NEURONAL AND MUSCLE CYTOPLASMIC ANTIBODIES

Purkinje Cell Cytoplasmic Antibody, Type 1 (PCA-1)

<1:2

Purkinje Cell Cytoplasmic Antibody, Type 2 (PCA-2)

<1:2

Purkinje Cell Cytoplasmic Antibody, Type TR (PCA-TR)

<1:2

Amphiphysin Antibody

<1:2

Collapsin Response-Mediator Protein-5 Neuronal (CRMP-5-IgG)

<1:2

 

AMPA-Receptor Antibody

CBA: Negative

IFA: <1:2

GABA-B-Receptor Antibody

CBA: Negative

IFA: <1:2

NMDA-Receptor Antibody

CBA: Negative

IFA: <1:2

LGI1-IgG

CBA: Negative

CASPR2-IgG

CBA: Negative

 

Neuronal Voltage-Gated Potassium Channel-Complex Autoantibody

≤0.02 nmol/L

 

WESTERN BLOT

Paraneoplastic Autoantibody, Western Blot Confirmation

Negative

Collapsin Response-Mediator Protein-5-IgG (CRMP-5-IgG) Western Blot

Negative

Amphiphysin Antibody Western Blot

Negative

Day(s) and Time(s) Performed

ANN1C, ANN2C, ANN3C, AGN1C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, NMDIC, AMPIC, GABIC: Monday through Friday; 11:30 a.m. and 8 p.m.; Saturday and Sunday 8 a.m.

AMPCC, GABCC, NMDCC, LG1CC, CS2CC: Monday through Friday; 6 a.m.

WBNC, CRMWC, ABLTC: Monday, Wednesday, Friday; 8 a.m.

VGKC: Monday through Friday 11 a.m. and 6 p.m.; Saturday 6 a.m.; Sunday 6 a.m.

CPT Code Information

84182-Paraneoplastic autoantibody Western blot confirmation (if appropriate)

84182-Amphiphysin Western blot confirmation (if appropriate)

84182-CRMP-5-IgG Western blot confirmation (if appropriate)86255-Amphiphysin (if appropriate)

86255-ANNA-1 (if appropriate)

86255-ANNA-2 (if appropriate)

86255-ANNA-3 (if appropriate)

86255-CRMP-5-IgG (if appropriate)

86255-PCA-1 (if appropriate)

86255-PCA-2 (if appropriate)

86255-PCA-Tr (if appropriate)

86255-AGNA-1 (if appropriate)

86256-AMPIC (if appropriate)

86256-GABIC (if appropriate)

86256-NMDIC (if appropriate)

86255-AMPCC (if appropriate)

86255-GABCC (if appropriate)

86255-NMDCC (if appropriate)

83519-VGKCC (if appropriate)

86255-LG1CC (if appropriate)

86255-CS2CC (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PNEFC Neuroimmunology Ab Follow-up, CSF In Process

 

Result ID Test Result Name Result LOINC Value
84299 Neuroimmunology Ab Follow-up, CSF No LOINC Needed

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
ANN1C Anti-Neuronal Nuclear Ab, Type 1 No No
ANN2C Anti-Neuronal Nuclear Ab, Type 2 No No
ANN3C Anti-Neuronal Nuclear Ab, Type 3 No No
AGN1C Anti-Glial Nuclear Ab, Type 1 No No
PCA1C Purkinje Cell Cytoplasmic Ab Type 1 No No
PCA2C Purkinje Cell Cytoplasmic Ab Type 2 No No
PCTRC Purkinje Cell Cytoplasmc Ab Type Tr No No
AMPHC Amphiphysin Ab, CSF No No
CRMC CRMP-5-IgG, CSF No No
NMDCC NMDA-R Ab CBA, CSF No No
AMPCC AMPA-R Ab CBA, CSF No No
GABCC GABA-B-R Ab CBA, CSF No No
NMDIC NMDA-R Ab IF Titer Assay, CSF No No
AMPIC AMPA-R Ab IF Titer Assay, CSF No No
GABIC GABA-B-R Ab IF Titer Assay, CSF No No
VGKCC VGKC-complex Ab IPA, CSF No No
ABLTC Amphiphysin Western Blot, CSF No No
CRMWC CRMP-5-IgG Western Blot, CSF No No
WBNC Paraneoplas Autoantibody WBlot,CSF No No
LG1CC LGI1-IgG CBA, CSF No No
CS2CC CASPR2-IgG CBA, CSF No No

Method Name

ANN1C, ANN2C, ANN3C, AGN1C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, NMDIC, AMPIC, GABIC: Indirect Immunofluorescence (IFA)

NMDCC, AMPCC, GABCC, LG1CC, CS2CC: Cell-Binding Assay (CBA)

WBNC, CRMWC, ABLTC: Western Blot

VGKCC: Radioimmunoassay (RIA)

Test Classification

Manually Entered

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/neurology-request-form.pdf)