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Test Code PNEFS Neuroimmunology Antibody Follow-up, Serum

Reporting Name

Neuroimmunology Ab Follow-up, S

Useful For

Monitoring patients who have previously tested positive for 1 or more antibodies in the Mayo Neuroimmunology Laboratory within the past 5 years.

 

Requests for the follow-up assay in serum specimens must have previously been positive in a serum evaluation.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum

Specimen Required

Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 4 mL

Specimen Minimum Volume

0.8 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

NEURONAL NUCLEAR ANTIBODIES

Antineuronal Nuclear Antibody-Type 1 (ANNA-1)

<1:240  

Antineuronal Nuclear Antibody-Type 2 (ANNA-2)  

<1:240

Antineuronal Nuclear Antibody-Type 3 (ANNA-3)

<1:240

 

NEURONAL AND MUSCLE CYTOPLASMIC ANTIBODIES

Purkinje Cell Cytoplasmic Antibody, Type 1 (PCA-1)

<1:240

Purkinje Cell Cytoplasmic Antibody, Type 2 (PCA-2)

<1:240

Purkinje Cell Cytoplasmic Antibody, Type Tr (PCA-Tr)

<1:240

Amphiphysin Antibody

<1:240

CRMP-5-IgG

<1:240

 

WESTERN BLOT

Paraneoplastic Autoantibody Western Blot Confirmation

Negative

CRMP-5-IgG Western Blot

Negative

Amphiphysin Western Blot

Negative

 

 

CATION CHANNEL ANTIBODIES

N-Type Calcium Channel Antibody

≤0.03 nmol/L

P/Q-Type Calcium Channel Antibody

≤0.02 nmol/L

AChR Ganglionic Neuronal Antibody

≤0.02 nmol/L

Neuronal VGKC Autoantibody

≤0.02 nmol/L

 

ACH RECEPTOR ANTIBODIES

ACh Receptor (Muscle) Modulating Antibodies

0-20% (reported as __% loss of AChR)

 

NMDA Receptor Antibody

CBA: Negative

IFA: <1:120

AMPA Receptor Antibody

CBA: Negative

IFA: <1:120

GABA-B Receptor Antibody

CBA: Negative

IFA: <1:120

LGI1-IgG

CBA: Negative

CASPR2-IgG

CBA: Negative

Day(s) and Time(s) Performed

ANN1S, ANN2S, ANN3S, AGN1S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AMPIS, GABIS, NMDIS: Monday through Friday; 11:30 a.m. and 8 p.m.; Saturday and Sunday 8 a.m.

AMPCS, GABCS, NMDCS. LG1CS, CS2CS: Monday through Friday; 6 a.m.

Paraneoplastic autoantibody Western blot confirmation, CRMP-5-IgG Western blot, Amphiphysin Western blot: Monday, Wednesday, Friday; 8 a.m.

CCPQ, CCN, GANG, VGKC: Monday through Friday 11 a.m. and 6 p.m.; Saturday 6 a.m.; Sunday 6 a.m.

ACh receptor (muscle) modulating antibodies: Monday through Thursday, Saturday; 12 p.m., Saturday; 8 a.m.

CPT Code Information

83519-59-ACh receptor (muscle) modulating antibodies (if appropriate)

83519-59-AChR ganglionic neuronal antibody (if appropriate)

83519-59-N-type calcium channel antibody (if appropriate)

83519-59-P/Q-type calcium channel antibody (if appropriate)

83519-VGKC (if appropriate)

84182-CRMP-5-IgG Western blot (if appropriate)

84182-Paraneoplastic autoantibody Western blot confirmation (if appropriate)

86255-Amphiphysin (if appropriate)

86255-ANNA-1 (if appropriate)

86255-ANNA-2 (if appropriate)

86255-ANNA-3 (if appropriate)

86255-CRMP-5-IgG (if appropriate)

86255-PCA-1 (if appropriate)

86255-PCA-2 (if appropriate)

86255-PCA-Tr (if appropriate)

86255-NMDCS (if appropriate)

86255-AMPCS (if appropriate)

86255-GABCS (if appropriate)

86256-NMDIS (if appropriate)

86256-AMPIS (if appropriate)

86256-GABIS (if appropriate)

86255-LG1CS (if appropriate)

86255-CS2CS (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PNEFS Neuroimmunology Ab Follow-up, S In Process

 

Result ID Test Result Name Result LOINC Value
84300 Neuroimmunology Ab Follow-up, S Unable to Verify

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
ANN1S Anti-Neuronal Nuclear Ab, Type 1 No No
ANN2S Anti-Neuronal Nuclear Ab, Type 2 No No
ANN3S Anti-Neuronal Nuclear Ab, Type 3 No No
AGN1S Anti-Glial Nuclear Ab, Type 1 No No
PCABP Purkinje Cell Cytoplasmic Ab Type 1 No No
PCAB2 Purkinje Cell Cytoplasmic Ab Type 2 No No
PCATR Purkinje Cell Cytoplasmic Ab Type Tr No No
AMPHS Amphiphysin Ab, S No No
CRMS CRMP-5-IgG, S No No
CCPQ P/Q-Type Calcium Channel Ab No No
CCN N-Type Calcium Channel Ab No No
GANG AChR Ganglionic Neuronal Ab, S No No
VGKC Neuronal (V-G) K+ Channel Ab, S No No
ARMO ACh Receptor (Muscle) Modulating Ab No No
NMDCS NMDA-R Ab CBA, S No No
AMPCS AMPA-R Ab CBA, S No No
GABCS GABA-B-R Ab CBA, S No No
NMDIS NMDA-R Ab IF Titer Assay, S No No
AMPIS AMPA-R Ab IF Titer Assay, S No No
GABIS GABA-B-R Ab IF Titer Assay, S No No
CRMWS CRMP-5-IgG Western Blot, S No No
WBN Paraneoplastic Autoantibody WBlot,S No No
ABLOT Amphiphysin Western Blot, S No No
LG1CS LGI1-IgG CBA, S No No
CS2CS CASPR2-IgG CBA, S No No

Method Name

ANN1S, ANN2S, ANN3S, AGN1S, PCABP, PCAB2, PCATR, AMPHS, CRMS, AMPIS, GABIS, NMDIS: Indirect Immunofluorescence (IFA)

AMPCS, GABCS, NMDCS, LG1CS, CS2CS: Cell-Binding Assay (CBA)

WBN, CRMWS, ABLOT: Western Blot

CCPQ, CCN, GANG, VGKC, ARMO: Radioimmunoassay (RIA)

Test Classification

Manually Entered

Forms

If not ordering electronically, complete, print, and send a Neurology Test Request Form-General (T732) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/neurology-request-form.pdf)