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Test Code XF5 Factor V Leiden (R506Q) Mutation, Blood

Additional Codes

XF5 (MWHC)

F5DNA (MAYO)

Reporting Name

Factor V Leiden (R506Q) Mutation, B

Useful For

Factor V Leiden mutation testing should be reserved for patients with clinically suspected thrombophilia and: 1) APC-resistance proven or suspected by a low or borderline APC-resistance ratio, or 2) a family history of factor V Leiden.

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Whole blood


Specimen Required


Container/Tube: 

Preferred: Yellow top (ACD)

Acceptable: EDTA or sodium citrate

Specimen Volume: Full tube

Collection Instructions: 

1. Invert several times to mix blood.

2. Send specimen in original tube.

Additional Information: Can be combined with other molecular coagulation tests;

-MTHAC 5,10-Methylenetetrahydrofolate Reductase A1298C, Mutation, Blood

-PTNT Prothrombin G20210A Mutation, Blood

-MTHFR 5,10-Methylenetetrahydrofolate Reductase C677T, Mutation, Blood

-MTHP 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Mutations, Blood


Specimen Minimum Volume

1 mL blood in a 3-mL ACD tube

Specimen Stability Information

Specimen Type Temperature Time
Whole blood Ambient (preferred) 7 days
  Frozen  14 days
  Refrigerated  14 days

Reference Values

Negative

Day(s) and Time(s) Performed

Monday through Friday; 12 p.m.

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81241-F5 (coagulation factor V) (eg, hereditary hypercoagulability) gene analysis, Leiden variant

 

LOINC Code Information

Test ID Test Order Name Order LOINC Value
F5DNA Factor V Leiden (R506Q) Mutation, B 21668-9

 

Result ID Test Result Name Result LOINC Value
21838 Factor V Leiden (R506Q) Mutation, B 21667-1
21839 F5DNA Interpretation 69049-5
21841 F5DNA Reviewed By 69047-9

Method Name

Direct Mutation Analysis

Forms

1. Coagulation Patient Information (T675) in Special Instructions

2. New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing form (T576) is available in Special Instructions.

3. If not ordering electronically, complete, print, and send a Coagulation Test Request Form (T753) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/coagulation-test-request-form.pdf)