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Test Code XOPIAT Opiates Confirmation, Urine

Additional Codes



Reporting Name

Opiate Confirmation, U

Useful For

Detection and quantification of codeine, hydrocodone, oxycodone, morphine, hydromorphone, oxymorphone, noroxycodone, noroxymorphone, norhydrocodone, dihydrocodeine, and naloxone in urine

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required

Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 20 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Additional Information:

1. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order OPATX / Opiates Confirmation, Chain of Custody, Urine.

2. If urine creatinine is required or adulteration of the sample is suspected, the following test should be requested, ADULT / Adulterants Survey, Urine. For additional information, refer to ADULT / Adulterants Survey, Urine.

3. Submitting <20 mL will compromise our ability to perform all necessary testing.

Specimen Minimum Volume

2.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values


Cutoff concentrations

Codeine by LC-MS/MS: 25 ng/mL

Dihydrocodeine-by LC-MS/MS: 25 ng/mL

Hydrocodone by LC-MS/MS: 25 ng/mL

Norhydrocodone-by LC-MS/MS: 25 ng/mL

Hydromorphone by LC-MS/MS: 25 ng/mL

Oxycodone by LC-MS/MS: 25 ng/mL

Noroxycodone-by LC-MS/MS: 25 ng/mL

Oxymorphone by LC-MS/MS: 25 ng/mL

Noroxymorphone-by LC-MS/MS: 25 ng/mL

Naloxone-by LC-MS/MS: 25 ng/mL

Morphine by LC-MS/MS: 25 ng/mL

Day(s) and Time(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information



G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OPATU Opiate Confirmation, U In Process


Result ID Test Result Name Result LOINC Value
6543 Codeine-by LC-MS/MS 3508-9
42000 Dihydrocodeine-by LC-MS/MS 19448-0
21177 Hydrocodone-by LC-MS/MS 3681-4
42001 Norhydrocodone-by LC-MS/MS 78868-7
21179 Hydromorphone-by LC-MS/MS 9835-0
21178 Oxycodone-by LC-MS/MS 11246-6
42002 Noroxycodone-by LC-MS/MS 77779-7
35023 Oxymorphone-by LC-MS/MS 17395-5
42003 Noroxymorphone-by LC-MS/MS No LOINC Needed
42004 Naloxone-by LC-MS/MS 77207-9
6542 Morphine-by LC-MS/MS 3831-5
21180 Opiates Interpretation 69050-3

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)