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Test Code VWFMS von Willebrand Factor Multimer Analysis, Plasma


Advisory Information


Coagulation testing is highly complex, often requiring the performance of multiple assays and correlation with clinical information. For that reason, we suggest ordering AVWPR / von Willebrand Disease Profile, Plasma.



Additional Testing Requirements


VWACT / von Willebrand Factor Activity, Plasma and VWAG / von Willebrand Factor Antigen, Plasma are requested but not required before performing this test. If already assayed, submit results. If no results are included, submit separate specimens for the above assays following specimen requirements for each test.



Shipping Instructions


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Specimen Required


See Coagulation Studies :Guidelines for Specimen Handling and Processing in Special Instructions..

 

Patient Preparation:

1. Fasting is preferred.

2. Specimen should be drawn prior to coagulation factor replacement therapy.

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again.

2. Aliquot plasma into a plastic vial leaving 0.25 mL in the bottom of centrifuged vial.

3. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally, ≤-40° C.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.


Forms

1. Coagulation Patient Information (T675) in Special Instructions.

2. If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.

Useful For

Resolving discrepancies when results of complementary laboratory tests (eg, F8A / Coagulation Factor VIII Activity Assay, Plasma; VWACT / von Willebrand Factor Activity, Plasma; and VWAG / von Willebrand Factor Antigen, Plasma) are abnormally low or discordant

 

Subtyping von Willebrand disease (VWD) (primarily identify variants of type 2 VWD)

 

Aiding in determining appropriate treatment

 

Identifying variants of type 2 VWD that have fewer of the largest multimers, have unusually large multimers, or have qualitatively abnormal "bands" that indicate an abnormal von Willebrand factor structure

Method Name

Agarose Gel Electrophoresis/Infrared Dye-Labeled Antibody Detection

Reporting Name

von Willebrand Factor Multimer, P

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 42 days

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Monday through Thursday (varies); 9 a.m.-4 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

85247

LOINC Code Information

Test ID Test Order Name Order LOINC Value
VWFMS von Willebrand Factor Multimer, P In Process

 

Result ID Test Result Name Result LOINC Value
603851 von Willebrand Factor Multimer, P No LOINC Needed
603855 VWF Multimer Interpretation 48595-3